Thiscompoundisaconjugateofsulforaphaneandglutathione.Invivo,sulforaphaneconjugateswithglutathioneduringmetabolism.Inanimalmodelsofprostatecancer,thisconjugatedisplaysantioxidativeandanticancerchemotherapeuticactivities,increasinglevelsofhemeoxygenase1(HO-1),Nrf2,activatedcaspase3,cleavedPARP,andBax,decreasinglevelsofKeap1,Bcl-xl,4E-BP1,mTOR,andcyclinD1,andslowingtumorgrowth.
| CasNo. | 289711-21-3 |
|---|---|
| Purity | ≥98% |
| Formula | C16H28N4O7S3 |
| FormulaWt. | 484.61 |
| IUPACName | L-γ-Glutamyl-S-{[4-(methylsulfinyl)butyl]carbamothioyl}-L-cysteinylglycine |
| Synonym | Sulforaphaneglutathioneconjugate |
| Solubility | Water |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | M1875InfoSheetPDF |
|---|---|
| Brochures | NaturalProductsBooklet |
KeumYS,KhorTO,LinW,etal.Pharmacokineticsandpharmacodynamicsofbroccolisproutsonthesuppressionofprostatecancerintransgenicadenocarcinomaofmouseprostate(TRAMP)mice:implicationofinductionofNrf2,HO-1andapoptosisandthesuppressionofAkt-dependentkinasepathway.PharmRes.2009Oct;26(10):2324-31.PMID:19669099.
