S-Trityl-L-cysteine(STLC)isanorganosulfurcompoundfoundingarlicplants.STLCexhibitsanticancerandpotentialchemotherapeuticactivitiesacrossseveralmodels.STLCactsasamitoticinhibitor,inhibitingmitotickinesinEg5andpreventingseparationofduplicatedchromosomesandformationofbipolarspindlesduringmitosis.Inchronicmyelogenousleukemia(CML)cells,STLCinducescleavageofpoly(ADP)-ribosepolymerase(PARP)andactivationofcaspase3,resultinginapoptosisandcelldeath.
| CasNo. | 2799-07-7 |
|---|---|
| Purity | ≥98% |
| Formula | C22H21NO2S |
| FormulaWt. | 363.47 |
| ChemicalName | S-(Triphenylmethyl)-L-cysteine |
| IUPACName | (2R)-2-amino-3-tritylsulfanylpropanoicacid |
| Synonym | NSC83265 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | T7232MSDSPDF |
|---|---|
| InfoSheet | T7232InfoSheetPDF |
| Brochures | NaturalProductsFlyer |
AbualhasanMN,GoodJA,WittayanarakulK,etal.Doingthemethyleneshuffle--furtherinsightsintotheinhibitionofmitotickinesinEg5withS-tritylL-cysteine.EurJMedChem.2012Aug;54:483-98.PMID:22749640.
ShimizuM,IshiiH,OgoN,etal.S-trityl-L-cysteinederivativeinducescaspase-independentcelldeathinK562humanchronicmyeloidleukemiacellline.CancerLett.2010Dec1;298(1):99-106.PMID:20619960.
KozielskiF,SkoufiasDA,IndoratoRL,etal.ProteomeanalysisofapoptosissignalingbyS-trityl-L-cysteine,apotentreversIBLeinhibitorofhumanmitotickinesinEg5.Proteomics.2008Jan;8(2):289-300.PMID:18186019.
SkoufiasDA,DeBonisS,SaoudiY,etal.S-trityl-L-cysteineisareversible,tightbindinginhibitorofthehumankinesinEg5thatspecificallyblocksmitoticprogression.JBiolChem.2006Jun30;281(26):17559-69.PMID:16507573.
