Description
Methylselenocysteine is found in plants in the Astragalus, Allium, and Brassica genera; it exhibits cytoprotective, chemopreventive, anti-angiogenic, antioxidative, and anti-inflammatory activities. Methylselenocysteine induces phase II enzyme activity and protects organs against chemotherapy-induced toxicity. In other models, methylselenocysteine increases expression of Nrf2, heme oxygenase 1 (HO-1), catalase, and glutathione-S-transferase, protecting against radiation-induced oxidative damage. Additionally, this compound decreases activation of NF-κB, p38 MAPK, and JNK and decreases expression of iNOS in LPS-stimulated macrophages.
References
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Shin HS, Yang WJ, Choi EM. The preventive effect of Se-methylselenocysteine on γ-radiation-induced oxidative stress in rat lungs. J Trace Elem Med Biol. 2013 Apr;27(2):154-9. PMID: 23176811.
Bhattacharya A. Methylselenocysteine: a promising antiangiogenic agent for overcoming drug delivery barriers in solid malignancies for therapeutic synergy with anticancer drugs. Expert Opin Drug Deliv. 2011 Jun;8(6):749-63. PMID: 21473705.
Pan MH, Hong HM, Lin CL, et al. Se-methylselenocysteine inhibits lipopolysaccharide-induced NF-κB activation and iNOS induction in RAW 264.7 murine macrophages. Mol Nutr Food Res. 2011 May;55(5):723-32. PMID: 21213327.
Zhang J, Wang L, Anderson LB, et al. Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model. Cancer Prev Res (Phila). 2010 Aug;3(8):994-1006. PMID: 20647336.
