Description
SesaminisaligninextractedfromtheseedsoftheSesaminindicumplant.Sesaminexhibitsantioxidativeandanticanceractivities.Incellularmodels,sesaminsuppressesSTAT3signaling,promotingcellcyclearrestandapoptosisofhepatocellularcarcinomacells.ThiscompoundactivatesERK/MAPKandp38signalingtoinduceosteoblastdifferentiationinvitroandreversespathologicalchangesassociatedwithosteoarthritisinvivo.Sesaminalsoprotectsagainstoxidativestressinspontaneouslyhypertensiveratsandanimalmodelsofoxidativeliverdamage.
References
DengP,WangC,ChenL,etal.SesaminInducesCellCycleArrestandApoptosisthroughtheInhibitionofSignalTransducerandActivatorofTranscription3SignallinginHumanHepatocellularCarcinomaCellLineHepG2.BiolPharmBull.2013;36(10):1540-1548.PMID:24088253.
LiuCM,ZhengGH,MingQL,etal.Sesaminprotectsmouseliveragainstnickel-inducedoxidativeDNAdamageandapoptosisbythePI3K-Aktpathway.JAgricFoodChem.2013Feb6;61(5):1146-54.PMID:23317420.
LiWX,KongX,ZhangJX,etal.Long-termintakeofsesaminimprovesleftventricularremodellinginspontaneouslyhypertensiverats.FoodFunct.2013Feb26;4(3):453-60.PMID:23238059.
PhitakT,PothacharoenP,SettakornJ,etal.Chondroprotectiveandanti-inflammatoryeffectsofsesamin.Phytochemistry.2012Aug;80:77-88.PMID:22704650.
WanachewinO,BoonmaleeratK,PothacharoenP,etal.Sesaminstimulatesosteoblastdifferentiationthroughp38andERK1/2MAPKsignalingpathways.BMCComplementAlternMed.2012May30;12:71.PMID:22646286.