Shikimicacidisoneofthebioactivecomponentsofcoconutwaterandcanbefoundinvariousplantsandmicroorganisms.Shikimicacidexhibitsantioxidativeandantinociceptiveactivitiesonitsown,althoughderivativesdisplayanti-inflammatorybenefitsaswell.Inhepatocytes,shikimicacidpreventsH2O2-inducedincreasesinROSlevelsandDNAdamageandactivatesNrf2signalingtoincreaseglutathioneandsuperoxidedismutaselevels.Additionally,thiscompoundinhibitschemically-inducedwrithinginanimalmodelsofpain.
| CasNo. | 138-59-0 |
|---|---|
| Purity | ≥98% |
| Formula | C7H10O5 |
| FormulaWt. | 174.15 |
| ChemicalName | [3R-(3α,3aβ,4α,7α,8a,8aα)]-2,3,4,7,8,8a-Hexahydro-4-hydroxy-8(hydroxymethyl)-8-methyl-1H-3a,7-methanoazulene-3,5-dicarboxylicacid |
| IUPACName | (3R,4S,5R)-3,4,5-trihydroxycyclohexene-1-carboxylicacid |
| Synonym | Shikimate |
| MeltingPoint | 183-184.5°C(lit.) |
| Solubility | Solubleinwater(1.8g/L).Practicallyinsolubleinchloroformandbenzene. |
| Appearance | Whitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | S3033MSDSPDF |
|---|---|
| InfoSheet | S3033InfoSheetPDF |
MannaK,KhanA,KrDasD,etal.ProtectiveeffectofcoconutwaterconcentrateanditsactivecomponentshikimicacidagainsthydroperoxidemediatedoxidativestressthroughsuppressionofNF-κBandactivationofNrf2pathway.JEthnopharmacol.2014May14.[Epubaheadofprint].PMID:24835026.
XingJ,YouC,DongK,etal.Ameliorativeeffectsof3,4-oxo-isopropylidene-shikimicacidonexperimentalcolitisandtheirmechanismsinrats.IntImmunopharmacol.2013Mar;15(3):524-31.PMID:23434856.
MorucciF,LopezP,MiñoJ,etal.AntinociceptiveactivityofaqueousextractandisolatedcompoundsofLithreamolleoides.JEthnopharmacol.2012Jul13;142(2):401-6.PMID:22609809.
