Description
Shikimic acid is one of the bioactive components of coconut water and can be found in various plants and microorganisms. Shikimic acid exhibits antioxidative and antinociceptive activities on its own, although derivatives display anti-inflammatory benefits as well. In hepatocytes, shikimic acid prevents H2O2-induced increases in ROS levels and DNA damage and activates Nrf2 signaling to increase glutathione and superoxide dismutase levels. Additionally, this compound inhibits chemically-induced writhing in animal models of pain.
References
Manna K, Khan A, Kr Das D, et al. Protective effect of coconut water concentrate and its active component shikimic acid against hydroperoxide mediated oxidative stress through suppression of NF-κB and activation of Nrf2 pathway. J Ethnopharmacol. 2014 May 14. [Epub ahead of print]. PMID: 24835026.
Xing J, You C, Dong K, et al. Ameliorative effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis and their mechanisms in rats. Int Immunopharmacol. 2013 Mar;15(3):524-31. PMID: 23434856.
Morucci F, Lopez P, Miño J, et al. Antinociceptive activity of aqueous extract and isolated compounds of Lithrea molleoides. J Ethnopharmacol. 2012 Jul 13;142(2):401-6. PMID: 22609809.
