LKT/APELIN-13，人/牛/A6017/0.5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/APELIN-13，人/牛/A6017/0.5 mg

LKT/APELIN-13，人/牛/A6017/0.5 mg

商品编号： A6017-0.5mg

品牌： lktlabs

市场价： ¥2000.00

美元价： 1200.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDA6017

CasNo.

Purity≥95%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Apelin-13isanendogenouspeptidethatexhibitsneuroprotectiveandpro-angiogenicactivities.Apelin-13bindsapelinreceptors(APJreceptors)thatheterodimerizewithbradykininreceptors;uponbinding,thiscomplexsignalsforincreasesinphosphorylationofeNOS,activationofPKC,andcellularproliferation.Apelin-13isalsoinvolvedintheregulationofwaterbalance,foodintake,nociception,andcardiovascularresponses.Invivoandinvitro,apelin-13increasesmyocardialglucoseuptakeandGLUT4membranetranslocationinanAMPK-dependentmanner.Inanimalmodelsofischemia/reperfusion,apelin-13decreasesneurologicaldeficits,infarctvolume,andbrainedema,andalsodownregulatesexpressionofBaxandcaspase3throughactivationofthePI3K/Aktsignalingpathway.Additionally,apelin-13promotesproliferation,migration,andtubeformationinmyocardialmicrovascularendothelialcells.

ProductInfo

ShippingandStorage

Purity	≥95%
Formula	C₆₉H₁₁₁N₂₃O₁₆S
FormulaWt.	1550.86
Appearance	Whitetooffwhitepowder

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

InfoSheet	A6017InfoSheetPDF

References

YangY,ZhangX,CuiH,etal.Apelin-13protectsthebrainagainstischemia/reperfusioninjurythroughactivatingPI3K/AktandERK1/2signalingpathways.NeurosciLett.2014Mar29;568C:44-49.[Epubaheadofprint].PMID:24686182.

BoB,LuluL,NingZ,etal.Heterodimerizationofhumanapelinandbradykinin1receptors:Novelsignaltransductioncharacteristics.CellSignal.2014Mar29.pii:S0898-6568(14)00124-7.[Epubaheadofprint].PMID:24686079.

YangX,ZhuW,ZhangP,etal.Apelin-13stimulatesangiogenesisbypromotingcrosstalkbetweenAMP-activatedproteinkinaseandAktsignalinginmyocardialmicrovascularendothelialcells.MolMedRep.2014May;9(5):1590-6.PMID:24573187.

XuS,HanP,HuangM,etal.Invivo,exvivo,andinvitrostudiesonapelin"seffectonmyocardialglucoseuptake.Peptides.2012Oct;37(2):320-6.PMID:22906703.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂