Description
Atomoxetinehydrochloride,alsoknownastomoxetinehydrochloride,isacommonlyprescribedtreatmentforavarietyofADHDsubtypes.Thiscompoundalsodisplaysminorantidepressantactivity,butisnotactiveenoughofitsowntowarrantprescriptionuseasatreatmentfordepression.Atomoxetinehydrochlorideinhibitsnorepinephrinetransporters(NET),increasingnorepinephrineanddopaminelevels,andinhibitsSEROtonintransporters(SERT)andN-methylD-aspartate(NMDA)receptorstoalesserdegree.Perhapsduetoitsmodulationofneurotransmitters,atomoxetineisalsocurrentlybeingstudiedasapotentialrelapsepreventiontherapyinrecentlyabstinentsubstanceabusesubjects.
References
IsakssonJ,HogmarkA,NilssonKW,etal.EffectsofstimulantsandatomoxetineoncortisollevelsinchildrenwithADHD.PsychiatryRes.2013Jul11.pii:S0165-1781PMID:23850434.
ErcanES,AkyolArdicU,KabukcuBasayB,etal.Atomoxetineresponseintheinattentiveandcombinedsubtypesofattentiondeficithyperactivitydisorder:aretrospectivechartreview.AttenDeficHyperactDisord.2013Jun5.[Epubaheadofprint].PMID:23737214.
SilverstonePH,DadashovaR.Atomoxetinetreatmentfornicotinewithdrawal:apilotdouble-blind,placebo-controlled,fixed-dosestudyinadultsmokers.AnnGenPsychiatry.2012Mar9;11(1):6.PMID:22405499.
EconomidouD,DalleyJW,EverittBJ.Selectivenorepinephrinereuptakeinhibitionbyatomoxetinepreventscue-inducedheroinandcocaineseeking.BiolPsychiatry.2011Feb1;69(3):266-74.PMID:21109233.
LudolphAG,UdvardiPT,SchazU,etal.AtomoxetineactsasanNMDAreceptorblockerinclinicallyrelevantconcentrations.BrJPharmacol.2010May;160(2):283-91.PMID:20423340.