Description
AWD131-138isapositiveallostericmodulatorofGABA-Areceptors;itactsatthebenzodiazepinesite.AWD131-138isusedinveterinarymedicinetotreatcanineepilepsyasitdisplaysanticonvulsantandantiepilepticactivities.Invariousanimalmodels,thiscompoundpreventsconvulsionsandthedevelopmentofepilepsyandincreasesseizurethresholds.
References
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LöscherW,HoffmannK,TweleF,etal.ThenovelantiepilepticdrugimepitoincomparesfavourablytootherGABA-mimeticdrugsinaseizurethresholdmodelinmiceanddogs.PharmacolRes.2013Nov;77:39-46.PMID:24056205.
YasarS,BergmanJ,MunzarP,etal.Evaluationofthenovelantiepilepticdrug,AWD131-138,forbenzodiazepine-likediscriminativestimulusandreinforcingeffectsinsquirrelmonkeys.EurJPharmacol.2003Apr4;465(3):257-65.PMID:12681437.