LKT/BACLOFEN/B0110/10 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/BACLOFEN/B0110/10 g

LKT/BACLOFEN/B0110/10 g

商品编号： B0110-10g

品牌： lktlabs

市场价： ¥4940.00

美元价： 2964.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDB0110

CasNo.1134-47-0

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

BaclofenisaGABAderivativethatactsasanagoNISTatGABA-Breceptors;itiscommonlyusedinanimalmodelstoexaminetheeffectsofGABAergicneurotransmissioninavarietyoffields,includingsubstancedependence,spasticity,pain,andfeedingbehavior.Baclofenexhibitsanalgesic,antinociceptive,andantiepileptic/anticonvulsantactivities.TheanalgesiceffectofbaclofenismediatedbyitsGABA-Breceptoractivation,inducingapresynapticblockofactionpotentialsinducedbymechanicalorthermalstimulithatdecreasesfrequencyandamplitudeofexcitatorypost-synapticcurrents.Baclofenisusedclinicallytopromoteabstinenceinalcoholdependentsubjects,potentiallymediatingalcoholcravingduringwithdrawal.Thiscompoundisalsodeliveredintrathecallytotreatspasticityanddystonia.

ProductInfo

CasNo.	1134-47-0
Purity	≥98%
Formula	C₁₀H₁₂ClNO₂
FormulaWt.	213.66
ChemicalName	β-(Aminomethyl)-4-chlorobenzenepropanoicacid
IUPACName	4-amino-3-(4-chlorophenyl)butanoicacid
Synonym	Baclon;Clofen;Lioresal
MeltingPoint	206-208°C
Solubility	SolubleinwaterorNaOH.
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

Downloads

MSDS	B0110MSDSPDF
InfoSheet	B0110InfoSheetPDF

References

FukuharaK,KatafuchiT,YoshimuraM.Effectsofbaclofenonmechanicalnoxiousandinnocuoustransmissioninthespinaldorsalhornoftheadultrat:invivopatch-clampanalysis.EurJNeurosci.2013Aug20.[Epubaheadofprint].PMID:23961926.

KumruH,KoflerM,FloresMC,etal.Effectofintrathecalbaclofenonevokedpainperception:anevokedpotentialsandquantitativethermaltestingstudy.EurJPain.2013Aug;17(7):1039-47.PMID:23239275.

BrennanJL,LeungJG,GagliardiJP,etal.Clinicaleffectivenessofbaclofenforthetreatmentofalcoholdependence:areview.ClinPharmacol.2013Jul3;5:99-107.PMID:23869179.

UchiyamaT,NakanishiK,FukawaN,etal.Neuromodulationusingintrathecalbaclofentherapyforspasticityanddystonia.NeurolMedChir(Tokyo).2012;52(7):463-9.PMID:22850493.

MinerP,BorkuhovaY,ShimonovaL,etal.GABA-AandGABA-BreceptorsmediatefeedingelicitedbytheGABA-Bagonistbaclofenintheventraltegmentalareaandnucleusaccumbensshellinrats:reciprocalandregionalinteractions.BrainRes.2010Oct8;1355:86-96.PMID:20696149.

LevyRA,ProudfitHK.Theanalgesicactionofbaclofen[beta-(4-chlorophenyl)-gamma-aminobutyricacid].JPharmacolExpTher.1977Aug;202(2):437-45.PMID:886473.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂