Bis(salicyl)fumarateisanaspirinanalogthatisusedtoinducehemoglobinchaincrosslinksatlysineresidues.Thiscompoundisusedtostudyhemoglobinfunctioninresearchmodelsandmaybeusedtodeveloptreatmentsforsickle-cellanemia.Thiscompoundmayexhibitanti-inflammatory,analgesic,andantipyreticactivities.
| Purity | ≥98% |
|---|---|
| Formula | C18H12O8 |
| FormulaWt. | 356.29 |
| MeltingPoint | 178-180°C |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | B3280InfoSheetPDF |
|---|
MacdonaldVW,MotterliniR.Vasoconstrictoreffectsinisolatedrabbitheartperfusedwithbis(3,5-dibromosalicyl)fumaratecross-linkedhemoglobin(alphaalphaHb).ArtifCellsBloodSubstitImmobilBiotechnol.1994;22(3):565-75.PMID:7994376.
ThompsonEB,KlotzIM.Pharmacologicalactionsofdiaspirins,potentialantisicklingagents:analgesicandanti-inflammatoryeffects.ResCommunChemPatholPharmacol.1985Jun;48(3):381-8.PMID:4023420.
ChatterjeeR,IwaiY,WalderRY,etal.Structuralfeaturesrequiredforthereactivityandintracellulartransportofbis(3,5-dibromosalicyl)fumarateandrelatedanti-sicklingcompoundsthatmodifyhemoglobinSatthe2,3-diphosphoglyceratebindingsite.JBiolChem.1984Dec10;259(23):14863-73.PMID:6501320.
