LKT/BUPIVACAINE HYDROCHLORIDE MONOHYDRATE/B8262/25 g-免疫在线蚂蚁淘旗下平台

商品详细LKT/BUPIVACAINE HYDROCHLORIDE MONOHYDRATE/B8262/25 g

LKT/BUPIVACAINE HYDROCHLORIDE MONOHYDRATE/B8262/25 g

商品编号： B8262-25g

品牌： lktlabs

市场价： ¥10480.00

美元价： 6288.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDB8262

CasNo.73360-54-0

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

BupivacaineisanaminoamideanestheticthatdecreasescurrentamplitudeandinhibitswholecellK+currentsinCa2+-activatedK+channelsandN-typevoltage-gated(Kv1/ShakerandKv3/Shaw[KCNAandKCNC])K+channels.Bupivacainealsoinhibitsvoltage-gatedNa+channelsandtandemporedomain(TASK-2/KCNK-5)K+channels.Bupivacainemaybeneurotoxicathighdoses,activatingp38MAPK,increasinglevelsofROSandWDR53,andinducingapoptosisinneuroblastomacells.Inothercellularmodels,bupivacaineinducesdepolarizationofthemitochondrialmembranepotential,resultinginapoptosis.

ProductInfo

CasNo.	73360-54-0
Purity	≥98%
Formula	C₁₈H₂₈N₂O•HCl•H₂O
FormulaWt.	342.91
ChemicalName	1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamidehydrochloridehydrate
IUPACName	1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrate;hydrochloride
Synonym	Bupivacainehydrochloridemonohydrate;Carbostesin;Marcaine;Sensorcaine
MeltingPoint	258.5°C
Solubility	Solubleinwater.Slightlysolubleinacetone,chloroformandether.
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	B8262MSDSPDF
InfoSheet	B8262InfoSheetPDF

References

HaratoM,HuangL,KondoF,etal.Bupivacaine-inducedapoptosisindependentlyofWDR35expressioninmouseneuroblastomaNeuro2acells.BMCNeurosci.2012Dec10;13:149.PMID:23227925.

MartínP,EnriqueN,PalomoAR,etal.Bupivacaineinhibitslargeconductance,voltage-andCa2+-activatedK+channelsinhumanumbilicalarterysmoothmusclecells.Channels(Austin).2012May-Jun;6(3):174-80.PMID:22688134.

LuJ,XuSY,ZhangQG,etal.Bupivacaineinducesapoptosisviamitochondriaandp38MAPKdependentpathways.EurJPharmacol.2011Apr25;657(1-3):51-8.PMID:21315711.

CelaO,PiccoliC,ScrimaR,etal.Bupivacaineuncouplesthemitochondrialoxidativephosphorylation,inhibitsrespiratorychaincomplexesIandIIIandenhancesROSproduction:resultsofastudyoncellcultures.Mitochondrion.2010Aug;10(5):487-96.PMID:20546950.

NilssonJ,MadejaM,ElinderF,etal.BupivacaineblocksN-typeinactivatingKvchannelsintheopenstate:noallostericeffectoninactivationkinetics.BiophysJ.2008Dec;95(11):5138-52.PMID:18790854.

KindlerCH,PaulM,ZouH,etal.AmidelocalanestheticspotentlyinhibitthehumantandemporedomainbackgroundK+channelTASK-2(KCNK5).JPharmacolExpTher.2003Jul;306(1):84-92.PMID:12660311.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂