LKT/CARNOSOL/C0267/5 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/CARNOSOL/C0267/5 mg

LKT/CARNOSOL/C0267/5 mg

商品编号： C0267-5mg

品牌： lktlabs

市场价： ¥4780.00

美元价： 2868.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDC0267

CasNo.5957-80-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Carnosolisaditerpenecompoundoriginallyfoundinrosemaryplants.Carnosolexhibitsantidepressant,anti-inflammatory,anti-angiogenic,andanticancerchemotherapeuticactivities.CarnosolinhibitsmicrosomalprostaglandinE2(PGE2)synthaseanddecreasesproductionofpro-inflammatoryPGE2;invivo,itinhibitsPMA-inducededemaanddecreasesexpressionofIL-1βandTNF-α.Carnosolinhibitstheepithelial-to-mesenchymaltransition(EMT)inovariancancercellsanddecreasesgrowthandviABIlityinbreast,ovarian,andintestinalcancercells.Incoloncancercells,carnosolincreasesactivationofcaspases3and9,inducescleavageofPARP,upregulatesexpressionofp53,downregulatesexpressionofMDM2,andsuppressesactivationofSTAT3,JAK2,andSrc.Additionally,thiscompoundinhibitsandrogenandestrogenreceptors,suppressingtumorgrowthandPSAlevelsinanimalmodelsofprostatecancer.

ProductInfo

CasNo.	5957-80-2
Purity	≥98%
Formula	C₂₀H₂₆O₄
FormulaWt.	330.42
ChemicalName	2H-9,4a-(Epoxymethano)phenanthren-12-one,1,3,4,9,110a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-,(4aR-(4aalpha,9alpha,10abeta))-
Synonym	CCRIS7122
MeltingPoint	210-220°C
Solubility	SolubleinDMSO,DMForethanol.Sparinglysolubleinaqueaousbuffers.
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	BlueIce

Downloads

InfoSheet	C0267InfoSheetPDF

References

VergaraD,SimeoneP,BettiniS,etal.Antitumoractivityofthedietaryditerpenecarnosolagainstapanelofhumancancercelllines.FoodFunct.2014Jun28;5(6):1261-9.PMID:24733049.

ParkKW,KunduJ,ChaeIG,etal.CarnosolinducesapoptosisthroughgenerationofROSandinactivationofSTAT3signalinginhumancoloncancerHCT116cells.IntJOncol.2014Apr;44(4):1309-15.PMID:24481553.

López-JiménezA,García-CaballeroM,MedinaMÁ,etal.Anti-angiogenicpropertiesofcarnosolandcarnosicacid,twomajordietarycompoundsfromrosemary.EurJNutr.2013Feb;52(1):85-95.PMID:22173778.

MachadoDG,CunhaMP,NeisVB,etal.Antidepressant-likeeffectsoffractions,essentialoil,carnosolandbetulinicacidisolatedfromRosmarinusofficinalisL.FoodChem.2013Jan15;136(2):999-1005.PMID:23122155.

BauerJ,KuehnlS,RollingerJM,etal.CarnosolandcarnosicacidsfromSalviaofficinalisinhibitmicrosomalprostaglandinE2synthase-1.JPharmacolExpTher.2012Jul;342(1):169-76.PMID:22511203.

MengoniES,VicheraG,RiganoLA,etal.SuppressionofCOX-2,IL-1βandTNF-αexpressionandleukocyteinfiltrationininflamedskinbybioactivecompoundsfromRosmarinusofficinalisL.Fitoterapia.2011Apr;82(3):414-21.PMID:21129455.

JohnsonJJ,SyedDN,SuhY,etal.Disruptionofandrogenandestrogenreceptoractivityinprostatecancerbyanoveldietaryditerpenecarnosol:implicationsforchemoprevention.CancerPrevRes(Phila).2010Sep;3(9):1112-23.PMID:20736335.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂