Description
Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-2; it exhibits anti-inflammatory, analgesic, anticancer, and anti-metastatic activities. Celecoxib is clinically used to treat arthritis, acute pain, and ankylosing spondylitis. In hepatoma cells, celecoxib decreases the mitochondrial membrane potential, increases cytochrome c release, activates caspases 3 and 9, alters Bcl-2 and Bax levels, and induces apoptosis. In vitro, celecoxib inhibits release of IL-6, IL-1β, and MIP-1α, suppresses phosphorylation of JNK, and activates SIRT1. Additionally, this compound inhibits invasion and migration of nasopharyngeal carcinoma cells by decreasing activity of matrix metalloproteinases 2 and 9 (MMP2/9).
References
Shao D, Kan M, Qiao P, et al. Celecoxib induces apoptosis via a mitochondria dependent pathway in the H22 mouse hepatoma cell line. Mol Med Rep. 2014 Oct;10(4):2093-8. PMID: 25109418.
Annamanedi M, Kalle AM. Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1. PLoS One. 2014 Jun 20;9(6):e99285. PMID: 24950067.
Li WW, Long GX, Liu DB, et al. Cyclooxygenase-2 inhibitor celecoxib suppresses invasion and migration of nasopharyngeal carcinoma cell lines through a decrease in matrix metalloproteinase-2 and -9 activity. Pharmazie. 2014 Feb;69(2):132-7. PMID: 24640603.
Shi S, Klotz U. Clinical use and pharmacological properties of selective COX-2 inhibitors. Eur J Clin Pharmacol. 2008 Mar;64(3):233-52. PMID: 17999057.
Subbaramaiah K, Howe LR, Bhardwaj P, et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila). 2011 Mar;4(3):329-346. PMID: 21372033.
