Sertralineexhibitsantidepressantandanxiolyticactivities;itisatypicalselectiveSEROtoninreuptakeinhibitor(SSRI).Sertralineprimarilyinhibitsthe5-HTtransporter(SERT),butalsoinhibitsthedopaminetransporter(DAT),α1-adrenergicreceptors,andpotentiallyσ1receptors.Additionally,sertralineinhibitsosteoclastformationandresorptionandinducesapoptosisinbothosteoclastsandosteoblasts.Thiscompoundalsoactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).
| CasNo. | 79559-97-0 |
|---|---|
| Purity | ≥98% |
| Formula | C17H17Cl2N•HCl |
| FormulaWt. | 342.70 |
| ChemicalName | (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenaminehydrochloride |
| IUPACName | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine;hydrochloride |
| Synonym | Lustral;Zoloft |
| MeltingPoint | 243-245°C |
| Solubility | Slightlysolubleinwaterandisopropylalcohol.Sparinglysolubleinethanol. |
| Appearance | AWhitetoOff-WhiteCrystallinePowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | S1971MSDSPDF |
|---|---|
| InfoSheet | S1971InfoSheetPDF |
GuaianaG,GuptaS,ChiodoD,etal.Agomelatineversusotherantidepressiveagentsformajordepression.CochraneDatabaseSystRev.2013Dec17;12:CD008851.PMID:24343836.
ZhuH,BogdanovMB,BoyleSH,etal.Pharmacometabolomicsofresponsetosertralineandtoplaceboinmajordepressivedisorder-possIBLeroleformethoxyindolepathway.PLoSOne.2013Jul17;8(7):e68283.PMID:23874572.
HodgeJM,WangY,BerkM,etal.Selectiveserotoninreuptakeinhibitorsinhibithumanosteoclastandosteoblastformationandfunction.BiolPsychiatry.2013Jul1;74(1):32-9.PMID:23260229.
MeyerJH,WilsonAA,SagratiS,etal.Serotonintransporteroccupancyoffiveselectiveserotoninreuptakeinhibitorsatdifferentdoses:an[11C]DASBpositronemissiontomographystudy.AmJPsychiatry.2004May;161(5):826-35.PMID:15121647.
