LKT/SPHINGOSINE-1-PHOSPHATE/S6130/1 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/SPHINGOSINE-1-PHOSPHATE/S6130/1 mg

LKT/SPHINGOSINE-1-PHOSPHATE/S6130/1 mg

商品编号： S6130-1mg

品牌： lktlabs

市场价： ¥4100.00

美元价： 2460.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

立即询价

商品介绍

ProductIDS6130

CasNo.26993-30-6

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Sphingosine-1-phosphate(S1P)isanendogenoussignalingsphingolipidproducedfrommetabolismofceramides.S1PbindstheS1PreceptorandmayinhibitHDACs.S1Pexhibitsneuroprotectiveactivityaswellasbothpro-inflammatoryandanti-inflammatoryproperties,dependingonthemodel.S1PincreasesneuronviABIlityandupregulatesexpressionofBcl-2andBcl-xl,inhibitingglucosedeprivationstress.S1PupregulatesexpressionofPAR4,promotingcellmigrationandCOX-2expressioninvitro.Clinically,S1Ppreservesfertilityandgonadalfunctioninsubjectsexposedtocytotoxicagentssuchaschemotherapeuticcompounds.

ProductInfo

CasNo.	26993-30-6
Purity	≥98%
Formula	C₁₈H₃₈NO₅P
FormulaWt.	379.47
ChemicalName	4-Octadecene-1,3-diol,2-amino-,1-(dihydrogenphosphate),(2S,3R,4E)-
IUPACName	[(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl]dihydrogenphosphateInChI:InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
Synonym	D-erythro-Sphingosine-1-phosphate
MeltingPoint	155°C
Solubility	Solubleinmethanol.
Appearance	WhiteSolid

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	S6130MSDSPDF
InfoSheet	S6130InfoSheetPDF

References

CzubowiczK,CieślikM,PyszkoJ,etal.Sphingosine-1-PhosphateandItsEffectonGlucoseDeprivation/GlucoseReloadStress:FromGeneExpressiontoNeuronalSurvival.MolNeurobiol.2014Jul24.[Epubaheadofprint].PMID:25056275.

Mahajan-ThakurS,SostmannBD,FenderAC,etal.Sphingosine-1-phosphateinducesthrombinreceptorPAR-4expressiontoenhancecellmigrationandCOX-2formationinhumanmonocytes.JLeukocBiol.2014Jul2.[Epubaheadofprint].PMID:24990321.

Nguyen-TranDH,HaitNC,SperberH,etal.Molecularmechanismofsphingosine-1-phosphateactioninDuchennemusculardystrophy.DisModelMech.2014Jan;7(1):41-54.PMID:24077965.

ZelinskiMB,MurphyMK,LawsonMS,etal.InvivodeliveryofFTY720preventsrADIation-inducedovarianfailureandinfertilityinadultfemalenonhumanprimates.FertilSteril.2011Mar15;95(4):1440-5.e1-7.PMID:21316047.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂