Description
Aprotininisapolypeptidethatexhibitsanti-fibrinolytic(pro-coagulant)activity.Aprotinininhibitsserineproteasessuchastrypsin,chymotrypsin,plasmin,andkallikrein.InhibitingtheseproteasespreventsformationofFactorXIIaandpreventsbreakdownofbloodclots.Aprotininisclinicallyusedduringsurgeriestopreventbleeding.
References
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KassellB,LaskowskiMSr.Thebasictrypsininhibitorofbovinepancreas.V.Thedisulfidelinkages.BiochemBiophysResCommun.1965Aug16;20(4):463-8.PMID:5860161.