Brain natriuretic peptide (BNP) binds the natriuretic peptide receptor type B (NPR-B) to exert cardiomodulatory activity. BNP is secreted by the heart; it displays lipolytic effects, contributing to fatty acid mobilization in congestive heart failure. High levels of BNP are predictive of cardiovascular problems such as heart failure and stroke. BNP also inhibits de novo collagen synthesis, increasing expression of matrix metalloproteinases 1, 2, and 3 in vitro.
| Cas No. | 114471-18-0 |
|---|---|
| Purity | ≥97% |
| Formula | C143H244N50O42S4 |
| Formula Wt. | 3464.1 |
| Synonym | Brain natriuretic peptide; BNP; Nesiritide |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | B5561 MSDS PDF |
|---|---|
| Info Sheet | B5561 Info Sheet PDF |
García-Berrocoso T, Giralt D, Bustamante A, et al. B-type natriuretic peptides and mortality after stroke: a systematic review and meta-analysis. Neurology. 2013 Dec 3;81(23):1976-85. PMID: 24186915.
Polak J, Kotrc M, Wedellova Z, et al. Lipolytic effects of B-type natriuretic peptide 1-32 in adipose tissue of heart failure patients compared with healthy controls. J Am Coll Cardiol. 2011 Sep 6;58(11):1119-25. PMID: 21884948.
Tsuruda T, Boerrigter G, Huntley BK, et al. Brain natriuretic Peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases. Circ Res. 2002 Dec 13;91(12):1127-34. PMID: 12480813.
