Description
Bigendothelin-1isacleavageprecursortoendothelin-1;secretionofthispeptideisstimulatedbyangiotensinII(ATII)andthrombin.Likeendothelin-1,bigendothelin-1exhibitsvasoconstrictive/hypertensiveactivity,increasingarteriolarconstrictionanddecreasingbloodflow.
References
LawrenceE,BrainSD.Bigendothelin-1andbigendothelin-3areconstrictoragentsinthemicrovasculature:evidenceforthelocalphosphoramidon-sensitiveconversionofbigendothelin-1.EurJPharmacol.1993Mar23;233(2-3):243-50.PMID:8467870.
KohnoM,YasunariK,YokokawaK,etal.Inhibitionbyatrialandbrainnatriureticpeptidesofendothelin-1secretionafterstimulationwithangiotensinIIandthrombinofculturedhumanendothelialcells.JClinInvest.1991Jun;87(6):1999-2004.PMID:1645748.