Big endothelin-1 is a cleavage precursor to endothelin-1; secretion of this peptide is stimulated by angiotensin II (AT II) and thrombin. Like endothelin-1, big endothelin-1 exhibits vasoconstrictive/hypertensive activity, increasing arteriolar constriction and decreasing blood flow.
| Cas No. | 124363-98-0 |
|---|---|
| Purity | ≥95% |
| Formula | C189H282N48O56S5 |
| Formula Wt. | 4282.96 |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | B3324 Info Sheet PDF |
|---|
Lawrence E, Brain SD. Big endothelin-1 and big endothelin-3 are constrictor agents in the microvasculature: evidence for the local phosphoramidon-sensitive conversion of big endothelin-1. Eur J Pharmacol. 1993 Mar 23;233(2-3):243-50. PMID: 8467870.
Kohno M, Yasunari K, Yokokawa K, et al. Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest. 1991 Jun;87(6):1999-2004. PMID: 1645748.
