Calcitonin gene-related peptide (CGRP) (8-37) inhibits the CGRP receptor and is used in research studies to examine the effects of CGRP. CGRP (8-37) inhibits the effects of ghrelin and induces caspase 3-mediated apoptosis in retinal cells of animal models of coronary artery occlusion. Like CGRP, this fragment likely binds RAMP1 and CGRP receptors.
| Cas No. | 129121-73-9 |
|---|---|
| Purity | ≥95% |
| Formula | C138H224N42O41 |
| Formula Wt. | 3127.58 |
| Synonym | CGRP (8-37) |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | C0249 MSDS PDF |
|---|---|
| Info Sheet | C0249 Info Sheet PDF |
Nguyen VT, Wu Y, Guillory AN, et al. Delta-opioid augments cardiac contraction through β-adrenergic and CGRP-receptor co-signaling. Peptides. 2012 Jan;33(1):77-82. PMID: 22108711.
Yang JH, Zhang YQ, Guo Z. Endogenous CGRP protects retinal cells against stress induced apoptosis in rats. Neurosci Lett. 2011 Aug 26;501(2):83-5. PMID: 21763400.
