Calcitoninisanendogenousneuropeptidethatexhibitspro-oncogenic,anti-osteoarthritic,andanti-resorptiveactivities.CalcitonininducesactivationofNF-κB,upregulatingexpressionandactivityoffibronectin,MMP-1,MMP-2,andMMP-9andincreasingcellgrowthinosteosarcomacells.WhenadmiNISTeredclinically,calcitoninincreasesserumNOandurinaryCTX-IIlevels,improvingmedialfemoralcondyleosteoarthritis.CalcitoninalsoinhibitsSCDP-inducedapoptosisofosteoclastsandincreasesboneformationandvolume.
| CasNo. | 9007-12-9 |
|---|---|
| Purity | ≥95% |
| Formula | C145H240N42O46S2 |
| FormulaWt. | 3371.91 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | C0146InfoSheetPDF |
|---|
TsagarakiI,PhenekosC,TsilibaryE,etal.Calcitonin-inducedNF-κBactivationup-regulatesfibronectinexpressioninMG63osteosarcomacells.AnticancerRes.2013Nov;33(11):4901-6.PMID:24222127.
ArmaganO,SerinDK,CalisirC,etal.Inhalationtherapyofcalcitoninrelievesosteoarthritisoftheknee.JKoreanMedSci.2012Nov;27(11):1405-10.PMID:23166425.
KuoYJ,TsuangFY,SunJS,etal.CalcitonininhibitsSDCP-inducedosteoclastapoptosisandincreasesitsefficacyinaratmodelofosteoporosis.PLoSOne.2012;7(7):e40272.PMID:22792258.
