RGD-4Cisacell-adhesivepeptidethatbindsαvβ3andαvβ5integrins;theseintegrinsareoverexpressedinmanycancersandgrowingvessels,soRGD-4Cisoftenattachedtoviraltreatmentstobetterdeliverortargetthetreatmenttocanceroustissues.RGD-4Cexhibitsanticancerchemotherapeuticandanti-angiogenicbenefitsinmodelsofvariouscancers,includingnon-smallcelllungcancer(NSCLC),melanoma,andglioma.
| Purity | ≥95% |
|---|---|
| Formula | C42H60N14O16S4 |
| FormulaWt. | 1145.29 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | R2510InfoSheetPDF |
|---|
AllaumeX,El-AndaloussiN,LeuchsB,etal.RetargetingofratparvovirusH-1PVtocancercellsthroughgeneticengineeringoftheviralcapsid.JVirol.2012Apr;86(7):3452-65.PMID:22258256.
PesonenS,DiaconuI,CerulloV,etal.IntegrintargetedoncolyticadenovirusesAd5-D24-RGDandAd5-RGD-D24-GMCSFfortreatmentofpatientswithadvancedchemotherapyrefractorysolidtumors.IntJCancer.2012Apr15;130(8):1937-47.PMID:21630267.
SarkiojaM,KanervaA,SaloJ,etal.Noninvasiveimagingforevaluationofthesystemicdeliveryofcapsid-modifiedadenovirusesinanorthotopicmodelofadvancedlungcancer.Cancer.2006Oct1;107(7):1578-88.PMID:16948124.
VanHoudtWJ,HavivYS,LuB,etal.Thehumansurvivinpromoter:anoveltranscriptionaltargetingstrategyfortreatmentofglioma.JNeurosurg.2006Apr;104(4):583-92.PMID:16619663.
