Rigin is a tuftsin-like tetrapeptide with the sequence G-Q-P-R that is derived from IgG. Rigin exhibits immunomodulatory activity, stimulating phagocytosis, activating polymorphonuclear lymphocytes and macrophages, and protecting against stress-induced damage.
| Cas No. | 77727-17-4 |
|---|---|
| Purity | ≥95% |
| Formula | C18H32N8O6 |
| Formula Wt. | 456.51 |
| IUPAC Name | (2S)-2-[[(2S)-1-[(2S)-5-amino-2-[(2-aminoacetyl)amino]-5-oxopentanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
| Synonym | G-Q-P-R; GQPR |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | R3224 Info Sheet PDF |
|---|
Dutta RC, Puri A, Anand N. Immunomodulatory potential of hydrophobic analogs of Rigin and their role in providing protection against Plasmodium berghei infection in mice. Int Immunopharmacol. 2001 May;1(5):843-55. PMID: 11379040.
Klusha VE, Mutsenietse RK, Svirskis ShV, et al. Neuroimmunoregulatory properties of short protein fragments in rats exposed to immobilization stress. Biull Eksp Biol Med. 1987 Aug;104(8):186-7. PMID: 2887222.
Veretennikova NI, Chipens GI, Nikiforovich GV, et al. Rigin, another phagocytosis-stimulating tetrapeptide isolated from human IgG. Confirmations of a hypothesis. Int J Pept Protein Res. 1981 Apr;17(4):430-5. PMID: 7309346.
