Small cardioactive peptide A (SCPA) is a peptide co-transmitter intrinsic to motor neurons that controls feeding behavior and muscle movement in molluscs such as species of Lymnea, Aplysia, and Clione. SCPA acts at the neuromuscular synapse, increasing cAMP; here, this peptide facilitates connection between cholinergic inhibitory neurons and sensory neurons. SCPA also controls feeding behavior, increasing feeding arousal.
| Cas No. | 98035-79-1 |
|---|---|
| Purity | ≥95% |
| Formula | C59H92N18O12S |
| Formula Wt. | 1277.57 |
| IUPAC Name | N-[2-[[1-[[1-[[1-[[1-[2-[[1-[(1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]-1-[2-(2-aminopropanoylamino)-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxamide |
| Synonym | SCPA |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet | S1060 Info Sheet PDF |
|---|
Fox LE, Lloyd PE. Role of cAMP in the short-term modulation of a neuromuscular system in aplysia. J Neurophysiol. 2000 Mar;83(3):1567-79. PMID: 10712480.
Storozhuk M, Castellucci VF. Modulation of cholinergic transmission in the neuronal network of the gill and siphon withdrawal reflex in Aplysia. Neuroscience. 1999 Apr;90(1):291-301. PMID: 10188955.
Perry SJ, Dobbins AC, Schofield MG, et al. Small cardioactive peptide gene: structure, expression and mass spectrometric analysis reveals a complex pattern of co-transmitters in a snail feeding neuron. Eur J Neurosci. 1999 Feb;11(2):655-62. PMID: 10051766.
Whim MD, Lloyd PE. Neuropeptide cotransmitters released from an identified cholinergic motor neuron modulate neuromuscular efficacy in Aplysia. J Neurosci. 1990 Oct;10(10):3313-22. PMID: 1976768.
