Speractisadecapeptidederivedfromtheouterenvelopeoftheegg;itstimulatesmotilityinspermatozoa.Speractactivatesitsownreceptor,areceptorinthescavengerreceptorfamily.SperactincreasesflagellarCa2+levelsandincreasesintracellularNa+,cAMP,andcGMP.SperactalsoactivatesK+channelsandaltersmembranepotential.
| CasNo. | 76901-59-2 |
|---|---|
| Purity | ≥95% |
| Formula | C38H57N11O14 |
| FormulaWt. | 891.94 |
| IUPACName | 3-[[2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]-4-[[1-[[4-amino-1-[[2-[[2-[[2-[[1-(carboxymethylamino)-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoicacid |
| Synonym | Sperm-activatingPeptideH-1 |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S6019InfoSheetPDF |
|---|
GuerreroA,NishigakiT,CarneiroJ,etal.Tuningspermchemotaxisbycalciumbursttiming.DevBiol.2010Aug1;344(1):52-65.PMID:20435032.
DarszonA,TreviñoCL,WoodC,etal.Ionchannelsinspermmotilityandcapacitation.SocReprodFertilSuppl.2007;65:229-44.PMID:17644965.
WoodCD,NishigakiT,TatsuY,etal.Alteringthesperact-inducedionpermeABIlitychangesthatgenerateflagellarCa2+spikesregulatestheirkineticsandseaurchinspermmotility.DevBiol.2007Jun15;306(2):525-37.PMID:17467684.
RodríguezE,DarszonA.Intracellularsodiumchangesduringthesperactresponseandtheacrosomereactioninseaurchinsperm.JPhysiol.2003Jan1;546(Pt1):89-100.PMID:12509481.
CardulloRA,HerrickSB,PetersonMJ,etal.Speractreceptorsarelocalizedonseaurchinspermflagellausingafluorescentpeptideanalog.DevBiol.1994Apr;162(2):600-7.PMID:8150218.
BabcockDF,BosmaMM,BattagliaDE,etal.EarlypersistentactivationofspermK+channelsbytheeggpeptidesperact.ProcNatlAcadSciUSA.1992Jul1;89(13):6001-5.PMID:1631086.
