AZD-1152inhibitsaurorakinasesBandC(AurB,AurC),preventingmitoticspindleformationandpropercompletionofmitosis.Thiscompoundexhibitsanticancerchemotherapeuticactivityandiscurrentlyinclinicaltrialsasapotentialtreatmentforcancerswithsolidtumors.Inacutemyelogenousleukemia(AML)andacutelymphocyticleukemia(ALL)cells,AZD-1152inducesapoptosis,inhibitingproliferation.AZD-1152alsoinducesapoptosisingliomacells,inhibitingproliferationinvitroandtumorgrowthinvivo.
| CasNo. | 722544-51-6 |
|---|---|
| Purity | ≥98% |
| Formula | C26H30FN7O3 |
| FormulaWt. | 507.56 |
| IUPACName | 2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide |
| Synonym | Barasertib;AZD1152 |
| Appearance | Off-whitePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | A9714MSDSPDF |
|---|---|
| InfoSheet | A9714InfoSheetPDF |
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DiazRJ,GolbournB,ShekarforoushM,etal.AurorakinaseB/Cinhibitionimpairsmalignantgliomagrowthinvivo.JNeurooncol.2012Jul;108(3):349-60.PMID:22382783.
BossDS,WitteveenPO,vanderSarJ,etal.ClinicalevaluationofAZD1152,ani.v.inhibitorofAuroraBkinase,inpatientswithsolidmalignanttumors.AnnOncol.2011Feb;22(2):431-7.PMID:20924078.
