AZD-1208isaPim-1kinaseinhibitorthatexhibitsanticancerchemotherapeuticactivity.Inacutemyelogenousleukemia(AML)cells,AZD-1208inducescellcyclearrestandapoptosis,inhibitingphosphorylationofdownstreamtargetssuchasBcl-2,4EBP1,p70S6K,andS6andsuppressingcellgrowth.Invivo,AZD-1208inhibitsgrowthofprostatetumorxenografts.
| CasNo. | 1204144-28-4 |
|---|---|
| Purity | ≥98% |
| Formula | C21H21N3O2S |
| FormulaWt. | 379.48 |
| IUPACName | (5E)-5-[[2-[(3R)-3-aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione |
| Appearance | PaleYellowPowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A9708InfoSheetPDF |
|---|
KirschnerAN,WangJ,vanderMeerR,etal.PIMkinaseinhibitorAZD1208fortreatmentofMYC-drivenprostatecancer.JNatlCancerInst.2014Dec13;107(2).PMID:25505253.
KeetonEK,McEachernK,DillmanKS,etal.AZD1208,apotentandselectivepan-Pimkinaseinhibitor,demonstratesefficacyinpreclinicalmodelsofacutemyeloidleukemia.Blood.2014Feb6;123(6):905-13.PMID:24363397.
