Description
AZD-2014isaninhibitorofmTORC1/2thatexhibitsanticancerchemotherapeuticactivity.AZD-2014inducesautophagyandinhibitsgrowthwithoutcausingapoptosisincolorectalcancercells.Inanimalmodels,AZD-2014inhibitstumorgrowthofcolorectalcancerxenografts.
AZD-2014isaninhibitorofmTORC1/2thatexhibitsanticancerchemotherapeuticactivity.AZD-2014inducesautophagyandinhibitsgrowthwithoutcausingapoptosisincolorectalcancercells.Inanimalmodels,AZD-2014inhibitstumorgrowthofcolorectalcancerxenografts.
CasNo. | 1009298-59-2 |
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Purity | ≥98% |
Formula | C25H30N6O3 |
FormulaWt. | 462.54 |
IUPACName | 3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide |
Appearance | YellowPowder |
StoreTemp | 4°C |
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ShipTemp | Ambient |
InfoSheet | A9710InfoSheetPDF |
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Brochures | PI3K-Akt-mTORCPathwayBooklet |
HuoHZ,ZhouZY,WangB,etal.DramaticsuppressionofcolorectalcancercellgrowthbythedualmTORC1andmTORC2inhibitorAZD-2014.BiochemBiophysResCommun.2014Jan10;443(2):406-12.PMID:24309100.