AZD-3463isaninhibitorofanaplasticlymphomakinase(ALK)andinsulin-likegrowthfactor1receptor(IGF-1R).Thiscompoundexhibitsanticancerchemotherapeuticactivity,inhibitingproliferationbyalteringdownstreamERK/Akt/STAT3signaling.AZD-3463hasinducedregressionorstasisininvivolungcancertumormodelsandinseveraldrug-resistantcelllines.
| CasNo. | 1356962-20-3 |
|---|---|
| Purity | ≥99% |
| Formula | C24H25ClN6O |
| FormulaWt. | 448.95 |
| IUPACName | N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine |
| Synonym | AZD3463 |
| Solubility | InDMSO,waterwith1eq.ofacid |
| Appearance | Yellowpowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A9600InfoSheetPDF |
|---|
Abstract:YangB.DiscoveryofAZD3463asanovelALK/IGFRdualinhibitoranditsABIlityinovercomingacquiredresistancetocrizotinib.ProteinKinasesinDrugDiscoveryConference.2013.
