AZD-4547isaninhibitorofFGFRthatissomewhatselectiveforFGFR2overFGFR1andFGFR3;itexhibitsanticancerchemotherapeuticactivities.Thiscompoundiscurrentlyinclinicaltrialsasapotentialtreatmentforbreastcancer.Inbreastcancercells,AZD-4547inducesapoptosisandinhibitscellularproliferation,invasionandmigration.Invivo,thiscompoundinhibitstumorgrowthandmetastasis.
| CasNo. | 1035270-39-3 |
|---|---|
| Purity | ≥98% |
| Formula | C26H33N5O3 |
| FormulaWt. | 463.57 |
| Synonym | AZD-4547 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A9814InfoSheetPDF |
|---|
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GavinePR,MooneyL,KilgourE,etal.AZD4547:anorallybioavailable,potent,andselectiveinhibitorofthefibroblastgrowthfactorreceptortyrosinekinasefamily.CancerRes.2012Apr15;72(8):2045-56.PMID:22369928.
