AZD-7762isaninhibitorofcheckpointkinase1(Chk1)thatincreasessensitivitytoDNA-damagingcompounds.AZD-7762exhibitsanticancerchemotherapeuticactivityandiscurrentlyinclinicaltrialsasapotentialtreatmentforavarietyofcancers.Inbreastcancerandovariancancercells,AZD-7762inhibitscellularproliferation.Inanimalmodelsofbreastcancer,AZD-7762inhibitstumorgrowthandincreasessurvivalrates.Thiscompounddisplayssomewhatlimitedefficacyduetocardiactoxicity.
| CasNo. | 860352-01-8 |
|---|---|
| Purity | ≥98% |
| Formula | C17H19FN4O2S•HCl |
| FormulaWt. | 398.88 |
| Synonym | AZD-7762HCl |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | A9912InfoSheetPDF |
|---|
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