BAY80-6946isaninhibitorofp110αPI3Kthatexhibitsanticancerchemotherapeuticactivity.BAY80-6946iscurrentlyinclinicaltrialsandshowssomebenefitinthetreatmentofpancreaticcancer.Incellularandanimalmodelsofmultiplemyeloma,BAY80-6946inhibitscellcycleprogression,inducesapoptosis,andinhibitscellproliferationandtumorgrowth.
| CasNo. | 1032568-63-0 |
|---|---|
| Purity | ≥98% |
| Formula | C23H28N8O4 |
| FormulaWt. | 480.52 |
| IUPACName | 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide |
| Synonym | Copanlisib |
| Solubility | Duetoitschemicalnature,pureBAY80-6946solidpowderwasfoundtohaveverylowsolubilityincommonorganicsolvents.Thishasbeenreportedintheliterature.Usermayusethefollowingmethodasareferencewhenmakingstocksolution:2mgBAY80-6946isplacedinaclearvial.Tothisvial,10µL10%HClisadded.ThevialiscappedandshakenforafewsecondstoallowHClsolutiontowetthecrystalsofBAY80-6946.Then90µLwaterisadded,andshakenforafewsecond,whichwillgiveaclearstocksolutionat20mg/mL.Thissolutioncanbefurtherdilutedusing0.5%HClwatersolution.PureBAY80-6946hasverylowsolubility,becauseofitschemicalproperty,notbecauseofthepoorqualityofourproduct.MoleculeofBAY80-6946containsseveralbasicnitrogenatoms,afterprotonatedbyHCl,itssolubilitywillbeenhanced.Forinvitrostudies,5mmol/LstocksolutionofBAY80-6946(indimethylsulfoxidewith10mmol/Ltrifluoroaceticacid)wasused-seeMolCancerTher.2013Nov;12(11):2319-30. |
| Appearance | FaintPink-PurplePowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | B0396InfoSheetPDF |
|---|
GlauerJ,PletzN,SchönM,etal.Anovelselectivesmall-moleculePI3Kinhibitoriseffectiveagainsthumanmultiplemyelomainvitroandinvivo.BloodCancerJ.2013Sep6;3:e141.PMID:24013662.
ChengH,MerikaE,SyrigosKN,etal.Novelagentsforthetreatmentofpancreaticadenocarcinoma.Highlightsfromthe"2011ASCOAnnualMeeting".Chicago,IL,USA;June3-7,2011.JOP.2011Jul8;12(4):334-8.PMID:21737890.
