BEZ235inhibitsPI3KandmTORC1/2,exhibitinganticancerchemotherapeuticactivity.Innasopharyngealcancercells,BEZ235inducesG1phasecellcyclearrestandapoptosis;insimilaranimalmodelsofnasopharyngealorcholangiocarcinoma,thiscompoundinhibitstumorgrowth.BEZ235alsoinducesapoptosisinhepatocellularcarcinomacells,alsopotentiallyinducingautophagy.
| CasNo. | 915019-65-7 |
|---|---|
| Purity | ≥98% |
| Formula | C30H23N5O |
| FormulaWt. | 469.54 |
| IUPACName | 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile |
| Synonym | NVP-BEZ235,Dactolisib |
| Appearance | WhiteCrystalPowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | B1996InfoSheetPDF |
|---|---|
| Brochures | PI3K-Akt-mTORCPathwayBooklet |
MaBB,LuiVW,HuiCW,etal.PreclinicalevaluationofthemTOR-PI3KinhibitorBEZ235innasopharyngealcancermodels.CancerLett.2014Feb1;343(1):24-32.PMID:24041865.
YothaisongS,DokduangH,TechasenA,etal.IncreasedactivationofPI3K/AKTsignalingpathwayisassociatedwithcholangiocarcinomametastasisandPI3K/mTORinhibitionpresentsapossIBLetherapeuticstrategy.TumourBiol.2013Dec;34(6):3637-48.PMID:23832540.
ChangZ,ShiG,JinJ,etal.DualPI3K/mTORinhibitorNVP-BEZ235-inducedapoptosisofhepatocellularcarcinomacelllinesisenhancedbyinhibitorsofautophagy.IntJMolMed.2013Jun;31(6):1449-56.PMID:23588698.
