BleomycinA5isananticancerchemotherapeuticthatbindsDNAandinducesDNAcleavageandstrandbreaks;itishighlytoxic.Bleomycinisclinicallyusedtotreatlymphomas,squamouscellcarcinomas,andtesticularcancer.Additionally,thiscompoundinducesapoptosis,alterscellcycleregulation,inhibitsproliferation,anddecreasestumorsizeincellularandanimalmodelsofhemangioma.Bleomycinmayalsoinhibitthioredoxinreductase.
| CasNo. | 55658-47-4 |
|---|---|
| Purity | ≥90% |
| Formula | C57H89N19O21S2•HCl |
| FormulaWt. | 1477.02 |
| IUPACName | [2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[5-[[1-[2-[4-[4-[3-(4-aminobutylamino)propylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]carbamate;hydrochlorideInChI:InChI=1S/C57H89N19O21S2.ClH/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53(91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(89)67-13-8-34-71-30(20-98-34)54-72-29(19-99-54)50(88)66-12-7-11-64-10-6-5-9-58;/h16,19-21,23-27,31-32,36-45,55-56,64,68,77-79,81-85H,5-15,17-18,58-59H2,1-4H3,(H2,60,80)(H2,62,86)(H2,63,92)(H,65,69)(H,66,88)(H,67,89)(H,70,91)(H,74,87)(H,75,90)(H2,61,73,76);1H |
| Synonym | Pingyangmycinhydrochloride |
| Solubility | Freelysolubleinwater,slightlysolubleinethanol |
| Appearance | WhiteCrystalPowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| MSDS | B4517MSDSPDF |
|---|---|
| InfoSheet | B4517InfoSheetPDF |
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