BMS-599626isapan-HERinhibitor(includingEGFRandVEGFR)thatiscurrentlyinclinicaltrialsasapotentialtreatmentagainstseveralformsofcancer.BMS-599626displaysanticancerchemotherapeuticactivity.Inheadandnecksquamouscellcarcinomacells,BMS-599626inducesG1phasecellcyclearrestandinhibitscellgrowth;invivo,itimprovesresponsestorADIation.
| CasNo. | 714971-09-2 |
|---|---|
| Purity | ≥98% |
| Formula | C27H27FN8O3 |
| FormulaWt. | 530.55 |
| Synonym | BMS599626,AC480 |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | B5074InfoSheetPDF |
|---|
SoriaJC,CortesJ,MassardC,etal.PhaseIsafety,pharmacokineticandpharmacodynamictrialofBMS-599626(AC480),anoralpan-HERreceptortyrosinekinaseinhibitor,inpatientswithadvancedsolidtumors.AnnOncol.2012Feb;23(2):463-71.PMID:21576284.
TorresMA,RajuU,MolkentineD,etal.AC480,formerlyBMS-599626,apanHerinhibitor,enhancesradiosensitivityandradioresponseofheadandnecksquamouscellcarcinomacellsinvitroandinvivo.InvestNewDrugs.2011Aug;29(4):554-61.PMID:20119866.
