BMS-911543 is an oral selective inhibitor of JAK2 currently in clinical trials. BMS-911543 shows anticancer activity through inhibition of the JAK/STAT signaling cascade in in vitro and in vivo models of myeloproliferative neoplasms, which display constitutively active JAK2 signaling. This compound exhibits antiproliferative and anti-erythropoetic effects.
| Cas No. | 1271022-90-2 |
|---|---|
| Purity | ≥99% |
| Formula | C23H28N8O |
| Formula Wt. | 432.52 |
| Synonym | BMS911543 |
| Solubility | Soluble in DMSO |
| Appearance | Off-White Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | B5000 MSDS PDF |
|---|---|
| Info Sheet | B5000 Info Sheet PDF |
| Brochures | JAK/STAT Flyer |
Purandare AV, McDevitt TM, Wan H, et al. Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2. Leukemia. 2012 Feb;26(2):280-8. PMID: 22015772.
Tibes R, Bogenberger JM, Geyer HL, et al. JAK2 inhibitors in the treatment of myeloproliferative neoplasms. Expert Opin Investig Drugs. 2012 Dec;21(12):1755-74. PMID: 22991927.
