Statilinhibitsaldosereductaseandexhibitsanticanceractivity;itisprimarilyusedtostudyaldosereductasefunctioninvitro.Inbreastcancerandlungcancercells,statilinhibitscellgrowthandproliferationandinducesapoptosis.StatilalsoenhancesADIpose-derivedstemadipocytedifferentiation.
| CasNo. | 72702-95-5 |
|---|---|
| Purity | ≥98% |
| Formula | C17H12BrFN2O3 |
| FormulaWt. | 391.19 |
| IUPACName | [3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1-phthalazinyl]aceticacid |
| Synonym | Ponalrestat |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S7601InfoSheetPDF |
|---|
PastelE,PointudJC,LoubeauG,etal.AldosereductasesinfluenceprostaglandinF2αlevelsandadipocytedifferentiationinmalemouseandhumanspecies.Endocrinology.2015May;156(5):1671-84.PMID:25730106.
CaoZ,ZhouB,ChenX,etal.StatilsuppressescancercellgrowthandproliferationbytheinhibitionoftumorMarkerAKR1B10.AnticancerDrugs.2014Sep;25(8):930-7.PMID:24800887.
El-KabbaniO,RamslandP,DarmaninC,etal.Structureofhumanaldosereductaseholoenzymeincomplexwithstatil:anapproachtostructure-basedinhibitordesignoftheenzyme.Proteins.2003Feb1;50(2):230-8.PMID:12486717.
