Scriptaidisaninhibitorofhistonedeacetylasesthatexhibitsanticanceractivity.Innon-smallcelllungcancer(NSCLC)cells,scriptaiddownregulatesexpressionofChk1.Ingliomacells,scriptaidincreasesactivationofJNKandp38MAPK,expressionofp21andp27,andactivityofRas;italsodecreasesactivityoftelomerase,inducingapoptosisanddecreasingproliferation.Insomaticcellnucleartransfer,scriptaidimprovesthequalityofclonedmouseembryos.
| Purity | ≥98% |
|---|---|
| Formula | C18H18N2O4 |
| FormulaWt. | 326.35 |
| ChemicalName | 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoicacidhydroxyamide |
| IUPACName | 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide |
| Synonym | CGK1026 |
| Solubility | SolubleinDMSO(1mg/mL)ormethanol. |
| Appearance | Offwhitepowder |
| StoreTemp | 4°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | S1069InfoSheetPDF |
|---|
BuiHT,SeoHJ,ParkMR,etal.HistonedeacetylaseinhibitionimprovesactivationofribosomalRNAgenesandembryonicnucleolarreprogramminginclonedmouseembryos.BiolReprod.2011Nov;85(5):1048-56.PMID:21753193.
BrazelleW,KreahlingJM,GemmerJ,etal.Histonedeacetylaseinhibitorsdownregulatecheckpointkinase1expressiontoinducecelldeathinnon-smallcelllungcancercells.PLoSOne.2010Dec14;5(12):e14335.PMID:21179472.
SharmaV,KoulN,JosephC,etal.HDACinhibitor,scriptaid,inducesgliomacellapoptosisthroughJNKactivationandinhibitstelomeraseactivity.JCellMolMed.2010Aug;14(8):2151-61.PMID:19583803.
