Felodipine is a dihydropyridine antagonist at L-type cardiac Ca2+ channels. Felodipine exhibits antihypertensive, cardioprotective, and anti-inflammatory activities. In rat models of metabolic syndrome, felodipine decreases blood pressure, activation of NF-κB, and levels of serum insulin, ICAM-1, VCAM-1, and circulating macrophages. In animal models of cardiac ischemia/reperfusion, felodipine decreases infarct size.
| Cas No. | 72509-76-3 |
|---|---|
| Purity | ≥98% |
| Formula | C18H19Cl2NO4 |
| Formula Wt. | 384.25 |
| IUPAC Name | 5-O-ethyl 3-O-methyl4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
| Synonym | Flodil, Munobal, Penedil, Perfudal, Plendil |
| Melting Point | 142-145°C |
| Appearance | White to off white powder |
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
| MSDS | F1745 MSDS PDF |
|---|---|
| Info Sheet | F1745 Info Sheet PDF |
Tan HW, Xing SS, Bi XP, et al. Felodipine attenuates vascular inflammation in a fructose-induced rat model of metabolic syndrome via the inhibition of NF-kappaB activation. Acta Pharmacol Sin. 2008 Sep;29(9):1051-9. PMID: 18718174.
Kal JE, Spaan JA, van Wezel HB. Calcium channel blockade with felodipine does not affect metabolic coronary vasodilation in patients with coronary artery disease. J Cardiovasc Pharmacol. 2002 Feb;39(2):225-33. PMID: 11791008.
Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.
