Description
Fenofibrate is a fibric acid derivative fibrate compound that exhibits anti-hyperlipidemic, anti-fibrotic, and anticancer chemotherapeutic activities. Fenofibrate activates PPARα, stimulating lipoprotein lipase and increasing lipolysis; this results in decreases in overall triglyceride, VLDL, and LDL levels as well as increases in HDL levels. Fenofibrate decreases oxidative stress-induced expression of α-SMA, TGF-β1, IL-6, collagen-1, and TNF-α, preventing CCL4-induced hepatic fibrosis. Fenofibrate also upregulates expression of Bad, downregulates expression of Bcl-xl, survivin, cyclin D1, and CDK4, activates caspase-3 and NF-κB, and induces G0/G1 phase cell cycle arrest in breast cancer cells, suppressing cell and tumor growth in both in vitro and in vivo models.
