Description
FluvoxamineisaselectiveSEROtonin(5-HT)reuptakeinhibitor(SSRI)thatexhibitsantidepressant,anti-inflammatory,cardioprotective,andantioxidativeactivities.Fluvoxamineinhibitstheserotonintransporter(SERT)andalsoactivatespre-synaptic5-HT3receptors;thisincreasesCa2+levelsandactivatesσ1receptors,modulatingintracellularCa2+levelsandinducingglutamatereleaseinvivo.Incellularmodels,fluvoxamineinhibitsproductionofNOandTNF-α.Fluvoxaminedisplayscardioprotectivebenefitinanimalmodelsbypreventingtransverseaorticconstriction(TAC)-inducedmyocardialhypertrophyandimpairedleftventriclefractionalshortening.Inotheranimalmodels,thiscompoundincreaseslevelsofglutathioneanddecreaseslevelsofmalondialdehydeandmyeloperoxidase.Fluvoxaminemayalsoinduceboneloss,asitinhibitsosteoclastformationandresorptionandpreventsbonemineralizationbyosteoblasts.Thiscompoundalsoactsasafunctionalinhibitorofacidsphingomyelinase(FIASMA).
References
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