LKT/FORSKOLIN/F5668/1 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/FORSKOLIN/F5668/1 mg

LKT/FORSKOLIN/F5668/1 mg

商品编号： F5668-1mg

品牌： lktlabs

市场价： ¥600.00

美元价： 360.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDF5668

CasNo.66575-29-9

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

ForskolinisalaBDanediterpenefoundinColeusthatexhibitsvasodilatory,immunomodulatory,antihypertensive,anti-inflammatory,andanticancerchemotherapeuticactivities.Forskolinactivatesadenylylcyclase,increasinglevelsofcAMPandactivatingPKA.Forskolindecreasesintraocularpressureinanimalmodelsofglaucoma.Additionally,forskolininhibitsIL-2-inducedphosphorylationofSTAT5andactivationofJAK3,decreasingTcellproliferationinvivo.ThiscompoundalsodecreaseslevelsofGli1mRNAandinhibitsSmoactivity,suppressingsonichedgehog(Shh)signaling;thisinhibitsbasalcellcarcinomatumorgrowthinanimalmodels.Forskolinalsoactivatesproteinphosphatase2A(PP2A)andenhancesproteasomeactivity.Inairwaysmoothmusclecells,forskolininhibitsIL-1β-inducedexpressionofIL-8.

ProductInfo

CasNo.	66575-29-9
Purity	≥98%
Formula	C₂₂H₃₄O₇
FormulaWt.	410.50
ChemicalName	(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10-10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
IUPACName	[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate
Synonym	Colforsin;Boforsin
MeltingPoint	230-232°C
Solubility	SolubleinDMSO(5mg/mL)orethanol(6mg/ml).
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	F5668MSDSPDF
InfoSheet	F5668InfoSheetPDF
Brochures	HedgehogSignalingFlyer
	WNTBooklet

References

RodriguezG,RossJA,NagyZS,etal.Forskolin-inducIBLecAMPpathwaynegativelyregulatesT-cellproliferationbyuncouplingtheinterleukin-2receptorcomplex.JBiolChem.2013Mar8;288(10):7137-46.PMID:23341462.

MakinodanE,MarnerosAG.ProteinkinaseAactivationinhibitsoncogenicSonichedgehogsignallingandsuppressesbasalcellcarcinomaoftheskin.ExpDermatol.2012Nov;21(11):847-52.PMID:23163650.

AlasbahiRH,MelzigMF.ForskolinandderivativesastoolsforstudyingtheroleofcAMP.Pharmazie.2012Jan;67(1):5-13.PMID:22393824.

CristóbalI,Garcia-OrtiL,CirauquiC,etal.PP2Aimpairedactivityisacommoneventinacutemyeloidleukemiaanditsactivationbyforskolinhasapotentanti-leukemiceffect.Leukemia.2011Apr;25(4):606-14.PMID:21233840.

AsaiM,TsukamotoO,MinaminoT,etal.PKArapidlyenhancesproteasomeassemblyandactivityininvivocaninehearts.JMolCellCardiol.2009Apr;46(4):452-62.PMID:19059265.

KaurM,HoldenNS,WilsonSM,etal.Effectofbeta2-adrenoceptoragoNISTsandothercAMP-elevatingagentsoninflammatorygeneexpressioninhumanASMcells:aroleforproteinkinaseA.AmJPhysiolLungCellMolPhysiol.2008Sep;295(3):L505-14.PMID:18586957.

ZengS,ShenB,WenL,etal.ExperimentalstudiesoftheeffectofForskolinontheloweringofintraocularpressure.YanKeXueBao.1995Sep;11(3):173-6.PMID:8758848.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂