Gemfibrozilisafibratethatexhibitsanti-hyperlipidemicandantibacterialactivities.GemfibrozilactivatesPPARα,increasingsynthesisoflipoproteinlipase,whichresultsindecreasesinserumtotalcholesterol,VLDL,LDL,andtriglyceridelevelsandincreasesinserumHDLlevelsandApoAexpression.Invitro,gemfibrozilalsoinhibitsenoyl-CoAreductase,preventingfattyacidsynthesisandsuppressinggrowthinspeciesofLegionellaandMycobacterium.
| CasNo. | 25812-30-0 |
|---|---|
| Purity | ≥98% |
| Formula | C15H22O3 |
| FormulaWt. | 250.33 |
| ChemicalName | 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoicacid |
| IUPACName | 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoicacid |
| Synonym | Decrelip;Genlip;Lipozid;Lipur;Lopid |
| MeltingPoint | 61-63°C |
| Solubility | Solubleinwaterandacid(0.0019%).Solubleindilutebase(>1%). |
| Appearance | WhiteCrystalPowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | G1749MSDSPDF |
|---|---|
| InfoSheet | G1749InfoSheetPDF |
Reich-SlotkyR,KabbashCA,Della-LattaP,etal.GemfibrozilinhibitsLegionellapneumophilaandMycobacteriumtuberculosisenoylcoenzymeAreductasesandblocksintracellulargrowthofthesebacteriainmacrophages.JBacteriol.2009Aug;191(16):5262-71.PMID:19429621.
SirtoriCR,FranceschiniG,GianfranceschiG,etal.Activityprofileofgemfibrozilonthemajorplasmalipoproteinparameters.EurJEpidemiol.1992May;8Suppl1:120-4.PMID:1505648.
