GS-967inhibitsvoltage-gatedNa+channels,exhibitingantiepileptic,anticonvulsant,antanti-arrhythmicactivities.GS-967decreasesthecardiaclateNa+current.Invivo,thiscompounddecreasesseizurefrequencyandimprovessurvivalrates.Inrathearts,GS-967suppressesandpreventsventriculartachycardiaandfibrillation.
| CasNo. | 1262618-39-2 |
|---|---|
| Purity | ≥98% |
| Formula | C14H7F6N3O |
| FormulaWt. | 347.22 |
| IUPACName | 6-[4-(Trifluoromethoxy)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | G7200InfoSheetPDF |
|---|
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PezhoumanA,MadahianS,StepanyanH,etal.Selectiveinhibitionoflatesodiumcurrentsuppressesventriculartachycardiaandfibrillationinintactrathearts.HeartRhythm.2014Mar;11(3):492-501.PMID:24291413.
SicouriS,BelardinelliL,AntzelevitchC.AntiarrhythmiceffectsofthehighlyselectivelatesodiumchannelcurrentblockerGS-458967.HeartRhythm.2013Jul;10(7):1036-43.PMID:23524321.
