LKT/IBUDILAST/I0480/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/IBUDILAST/I0480/25 mg

LKT/IBUDILAST/I0480/25 mg

商品编号： I0480-25mg

品牌： lktlabs

市场价： ¥6200.00

美元价： 3720.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDI0480

CasNo.50847-11-5

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Ibudilastisaninhibitorofphosphodiesterases3and5(PDE3/5)thatalsoinhibitstheleukotrieneD4(LTD4)receptorinairwaysmoothmusclecells.Ibudilastexhibitsvasodilatory,anti-inflammatory,anti-asthma,anti-platelet,analgesic,andantinociceptiveactivities.Inclinicalsettings,ibudilastincreasescerebralbloodflowinseveralbrainregionsafterischemicstroke.Ibudilastalsonon-competitivelyinhibitsthefunctionsofpro-inflammatorymacrophagemigrationinhibitoryfactor(MIF),preventingglialcellactivation.Inothercellularmodels,ibudilastdecreasesactivationofNF-κB,inhibitingHIV-1Tat-inducedproductionofTNF-α.

ProductInfo

CasNo.	50847-11-5
Purity	≥98%
Formula	C₁₄H₁₈N₂O
FormulaWt.	230.31
IUPACName	2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
Synonym	3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine;2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone;2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine;KC-404,AV-411
MeltingPoint	53-54°C
Appearance	WhiteCrystalPowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	I0480MSDSPDF
InfoSheet	I0480InfoSheetPDF

References

InoueN,FukudaS,InadaT,etal.Effectofibudilastonthereciprocalinhibitoryvisual-vestibularinteractioncloselyrelatedtodizzinessaftercerebralischemia.JStrokeCerebrovascDis.2014Jan;23(1):51-5.PMID:23085301.

KiebalaM,MaggirwarSB.Ibudilast,apharmacologicphosphodiesteraseinhibitor,preventshumanimmunodeficiencyvirus-1Tat-mediatedactivationofmicroglialcells.PLoSOne.2011Apr8;6(4):e18633.PMID:21494611.

ChoY,CrichlowGV,VermeireJJ,etal.Allostericinhibitionofmacrophagemigrationinhibitoryfactorrevealedbyibudilast.ProcNatlAcadSciUSA.2010Jun22;107(25):11313-8.PMID:20534506.

LedeboerA,HutchinsonMR,WatkinsLR,etal.Ibudilast(AV-411).Anewclasstherapeuticcandidateforneuropathicpainandopioidwithdrawalsyndromes.ExpertOpinInvestigDrugs.2007Jul;16(7):935-50.PMID:17594181.

KishiY,OhtaS,KasuyaN,etal.Ibudilastmodulatesplatelet-endotheliuminteractionmainlythroughcyclicGMP-dependentmechanism.JCardiovascPharmacol.2000Jul;36(1):65-70.PMID:10892662.

OhashiM,KanaiR,NishinoK,etal.AntagoNISTiceffectofKC-404,anewanti-asthmaticagent,onleukotrieneD4-inducedcontractileresponsesinisolatedguineapigsmoothmuscles.Prostaglandins.1986Dec;32(6):875-88.PMID:3562868.

OhashiM,OhkuboH,KitoJ,etal.Anewvasodilator3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine(KC-404)hasadualmechanismofactiononplateletaggregation.ArchIntPharmacodynTher.1986Oct;283(2):321-34.PMID:3024600.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂