LKT/IMPERATORIN/I4961/25 mg-免疫在线蚂蚁淘旗下平台

商品详细LKT/IMPERATORIN/I4961/25 mg

LKT/IMPERATORIN/I4961/25 mg

商品编号： I4961-25mg

品牌： lktlabs

市场价： ¥5920.00

美元价： 3552.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDI4961

CasNo.482-44-0

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Imperatorinisafurocoumarinthatdisplaysawidevarietyofbeneficialproperties,includingantihypertensive,vasodilatory,antioxidative,antibacterial,anti-parasitic,cognitionenhancing,andneuroprotectiveactivities.Imperatorinincreaseslevelsofcatalase,xanthineoxidase,glutathione,NO,andNOSanddecreaseslevelsofangiotensinIIinhypertensiverats.Invitro,imperatorininducesNO-regulatedvasodilationinmousethoracicaortictissue.ThiscompoundisactiveagainstbothgrampositiveandgramnegativebacteriaandalsoshowstoxicityagainstCulexandAedesmosquitolarvae,indicatinginsecticidepotentialaswell.Invitro,imperatorininhibitscaspase-3andBaxexpressionandupregulatesBcl-2andBDNFexpression.Inanimalmodelsofcerebralischemia,imperatorindecreasesinfarctvolume.Additionally,thiscompoundinhibitsvoltage-gatedNa+channelsinrathippocampalneuronsanddisplaysinhibitoryactivityagainstbothbutyrlcholinesterase(BChE)andacetylcholinesterase(AChE).InanimalmodelsofAlzheimer’sdisease,imperatorinimprovesmemoryacquisitionandconsolidationprocesses.

ProductInfo

CasNo.	482-44-0
Purity	≥98%
Formula	C₁₆H₁₄O₄
FormulaWt.	270.28
IUPACName	9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one
Solubility	DMSO10mM.<0.3 mg/ml="" hot="">
Appearance	WhiteCrystals

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

InfoSheet	I4961InfoSheetPDF

References

GranicaS,KissAK,JarończykM,etal.SynthesisofImperatorinAnalogsandTheirEvaluationasAcetylcholinesteraseandButyrylcholinesteraseInhibitors.ArchPharm(Weinheim).2013Oct14.[Epubaheadofprint].PMID:24123207.

WuKC,ChenYH,ChengKS,etal.Suppressionofvoltage-gatedNa(+)channelsandneuronalexcitABIlitybyimperatorin.EurJPharmacol.2013Dec5;721(1-3):49-55.PMID:24113522.

BudzynskaB,Boguszewska-CzubaraA,Kruk-SlomkaM,etal.Effectsofimperatorinonnicotine-inducedanxiety-andmemory-relatedresponsesandoxidativestressinmice.PhysiolBehav.2013Oct2;122:46-55.PMID:23999469.

WangN,WuL,CaoY,etal.Theprotectiveactivityofimperatorininculturedneuralcellsexposedtohypoxiare-oxygenationinjuryviaanti-apoptosis.Fitoterapia.2013Oct;90:38-43.PMID:23856091.

KimuraY,SumiyoshiM,SakanakaM,etal.Invitroandinvivoantiproliferativeeffectofacombinationofultraviolet-AandalkoxyfurocoumarinsisolatedfromUmbelliferaemedicinalplants,inmelanomacells.PhotochemPhotobiol.2013Sep-Oct;89(5):1216-25.PMID:23802687.

CaoYJ,HeX,WangN,etal.Effectsofimperatorin,theactivecomponentfromRADIxAngelicae(Baizhi),onthebloodpressureandoxidativestressin2K,1Chypertensiverats.Phytomedicine.2013Sep15;20(12):1048-54.PMID:23746952.

WangZ,KimJR,WangM,etal.LarvicidalactivityofCnidiummonnierifruitcoumarinsandstructurallyrelatedcompoundsagainstinsecticide-susceptIBLeandinsecticide-resistantCulexpipienspallensandAedesaegypti.PestManagSci.2012Jul;68(7):1041-7.PMID:22389164.

WidelskiJ,PopovaM,GraikouK,etal.CoumarinsfromAngelicalucidaL.--antibacterialactivities.Molecules.2009Jul27;14(8):2729-34.PMID:19701119.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂