Description
Isofluraneisananestheticmostcommonlyusedinveterinarymedicine.Isofluraneexhibitscardiomodulatory,neuromodulatory,andpro-inflammatoryactivities.Indiabeticrats,isofluoranedecreasescardiacforceandintracellularCa2+amplitude.IsofluranealsoincreasesIL-6andNF-κBlevelsingliomacellsandmicroglia.Inothercellularmodels,isofluraneinhibitsL-typevoltage-gatedCa2+channelcurrentsatrestingmembranepotential.Additionally,isofluoranebindsandmodulatessignalingbyATPsynthaseandNADHdehydrogenase.IsofluranealsoinhibitsdelayedrectifierandA-typeK+channelsandNMDAreceptors,activatesCa2+ATPaseandATP-sensitiveK+channels,andpotentiatesGABA-Aandglycine(GlyR)receptors.