Isoproterenolisanon-selectiveβ-adrenergicreceptoragoNISTthatisclinicallyusedtotreatbradycardia,heartblock,andasthma;itexhibitsantihypertensive,bronchodilatory,andanti-asthmaactivities.Isoproterenolincreasessystolicbloodpressureanddecreasesdiastolicbloodpressure,producinganoveralldecreaseinmeanarterialpressure.Thepositiveinotropicactionofisoproterenolisoftenusedtoinducecardiacdysfunctionormyocardialinfarctioninresearchmodels.Isoproterenolalsoinducesrelaxationofairwaysmoothmuscle.
| CasNo. | 51-30-9 |
|---|---|
| Purity | ≥98% |
| Formula | C11H17NO3•HCl |
| FormulaWt. | 247.72 |
| IUPACName | hydron;4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol;chloride |
| Synonym | (+/-)-Isoprenalinehydrochloride;1-(3",4"-Dihydro-xyphenyl)-2-isopropylaminoethanolHydrochloride;N-Isopropyl-DL-noradrenalineHydrochloride |
| MeltingPoint | 165.5-170°C |
| Solubility | Solubleinwater(>300mg/L),ethanol(20mg/mL),andmethanol. |
| Appearance | Whitetooffwhitepowder |
| StoreTemp | Ambient |
|---|---|
| ShipTemp | Ambient |
| MSDS | I7259MSDSPDF |
|---|---|
| InfoSheet | I7259InfoSheetPDF |
GongLL,FangLH,WangSB,etal.Coptisineexertcardioprotectiveeffectthroughanti-oxidativeandinhibitionofRhoA/Rhokinasepathwayonisoproterenol-inducedmyocardialinfarctioninrats.Atherosclerosis.2012May;222(1):50-8.PMID:22387061.
GumpA,HaughneyL,FredbergJ.Relaxationofactivatedairwaysmoothmuscle:relativepotencyofisoproterenolvs.tidalstretch.JApplPhysiol(1985).2001Jun;90(6):2306-10.PMID:11356796.
GreenJF.Mechanismofactionofisoproterenolonvenousreturn.AmJPhysiol.1977Feb;232(2):H152-6.PMID:842647.
