LKT/KAWAIN/K0088/5毫克-免疫在线蚂蚁淘旗下平台

商品详细LKT/KAWAIN/K0088/5毫克

LKT/KAWAIN/K0088/5毫克

商品编号： K0088-5mg

品牌： lktlabs

市场价： ¥4100.00

美元价： 2460.00

产地：美国(厂家直采)

公司：

产品分类：临床研究

公司分类： clinical_research

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

ProductIDK0088

CasNo.3155-48-4

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

KawainisakavalactoneoriginallyfoundinPipermethysticum(kavaplant).Kawainexhibitsneuroprotective,hypnotic,sedative,anxiolytic,antiepileptic/anticonvulsant,antithrombotic,andantifungalactivities.KawainactivatesNrf2inneuronsandastroglia,protectingagainstamyloid-β(Aβ)-inducedneurotoxicity.ThiscompounddisplaysantimicrobialefficacyagainstspeciesofFusarium,Trichoderma,andColletotrichum.Inanimalmodels,Kawaindecreasessleeplatencyandtimeawakeandincreasesnon-REMsleeptimeanddeltaactivityduringREMsleep.Additionally,kawainbindsreceptorsite2andinhibitsvoltage-gatedNa+channels.KawainalsoinhibitsL-typevoltage-gatedCa2+channels.Thiscompoundalsoinhibitsarachidonicacid-inducedplateletaggregationandCOXexpression.

ProductInfo

CasNo.	3155-48-4
Purity	≥98%
Formula	C₁₄H₁₄O₃
FormulaWt.	230.26
ChemicalName	(6R)-5,6-Dihydro-4-methoxy-6-[(1E)-2-phenyl-ethenyl]-2H-pyran-2-one
IUPACName	4-methoxy-2-[(E)-2-phenylethenyl]-2,3-dihydropyran-6-one
Synonym	Kavain;Gonosan
MeltingPoint	105-106°C
Solubility	Solubleinacetone,etherormethanol.Slightlysolubleinhexane.Practicallyinsolubleinwater.
Appearance	Whitecrystallinepowder

ShippingandStorage

StoreTemp	-20°C
ShipTemp	Ambient

Downloads

MSDS	K0088MSDSPDF
InfoSheet	K0088InfoSheetPDF

References

TsutsuiR,ShinomiyaK,TakedaY,etal.Hypnoticandsleepquality-enhancingpropertiesofkavaininsleep-disturbedrats.JPharmacolSci.2009Nov;111(3):293-8.PMID:19881224.

WruckCJ,GötzME,HerdegenT,etal.Kavalactonesprotectneuralcellsagainstamyloidbetapeptide-inducedneurotoxicityviaextracellularsignal-regulatedkinase1/2-dependentnuclearfactorerythroid2-relatedfactor2activation.MolPharmacol.2008Jun;73(6):1785-95.PMID:18334601.

XuanTD,ElzaawelyAA,FukutaM,etal.HerbicidalandFungicidalActivitiesofLactonesinKava(Pipermethysticum).JAgricFoodChem.2006Feb8;54(3):720-5.PMID:16448174.

MartinHB,McCallumM,StoferWD,etal.Kavainattenuatesvascularcontractilitythroughinhibitionofcalciumchannels.PlantaMed.2002Sep;68(9):784-9.PMID:12357387.

FrieseJ,GleitzJ.Kavain,dihydrokavain,anddihydromethysticinnon-competitivelyinhibitthespecificbindingof[3H]-batrachotoxinin-A20-alpha-benzoatetoreceptorsite2ofvoltage-gatedNa+channels.PlantaMed.1998Jun;64(5):458-9.PMID:9690349.

MaguraEI,KopanitsaMV,GleitzJ,etal.Kavaextractingredients,(+)-methysticinand(+/-)-kavaininhibitvoltage-operatedNa(+)-channelsinratCA1hippocampalneurons.Neuroscience.1997Nov;81(2):345-51.Erratumin:Neuroscience1998May;84(1):323.PMID:9300426.

GleitzJ,BeileA,WilkensP,etal.Antithromboticactionofthekavapyrone(+)-kavainpreparedfromPipermethysticumonhumanplatelets.PlantaMed.1997Feb;63(1):27-30.PMID:9063093.

LindenbergD,Pitule-SchödelH.D,L-kavainincomparisonwithoxazepaminanxietydisorders.Adouble-blindstudyofclinicaleffectiveness.FortschrMed.1990Jan20;108(2):49-50,53-4.PMID:2179082.

品牌介绍

LKT Labs LKT Labs 是一家专注于防癌抗癌特殊化学品研究和开发的公司。主要提供：癌症药物、药物发现试剂盒、天然产物、广泛的生命科学研究试剂、定制合成。美国LKT Labs 是1988年在美国成立的，为全球提供先端的药物研发试剂、试剂盒、委托合成，并为药物生产企业提供原料，最近几年在农药、水产养殖业有很大程度的开发。在LKT Labs 可以找到在其他地方找不到的产品。试剂